More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration

نویسندگان

  • Courtney Lane-Donovan
  • Gary T. Philips
  • Joachim Herz
چکیده

Members of the low-density lipoprotein (LDL) receptor gene family have a diverse set of biological functions that transcend lipid metabolism. Lipoprotein receptors have broad effects in both the developing and adult brain and participate in synapse development, cargo trafficking, and signal transduction. In addition, several family members play key roles in Alzheimer's disease (AD) pathogenesis and neurodegeneration. This Review summarizes our current understanding of the role lipoprotein receptors play in CNS function and AD pathology, with a special emphasis on amyloid-independent roles in endocytosis and synaptic dysfunction.

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عنوان ژورنال:
  • Neuron

دوره 83  شماره 

صفحات  -

تاریخ انتشار 2014